Thermo Fisher Scientific PD-1 (CD279) Polyclonal Antibody
Rabbit polyclonal antibody targeting human PD-1 (CD279). Validated for WB, ICC/IF, and ELISA applications. Supplied in liquid form with 3.69 mg/mL concentration. Suitable for detecting PD-1 in immune response research. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 205–259 of human PD-1/CD279 (NP_005009.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.69 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901171 |
Product Specific Information
- Positive Samples: Raji, Mouse spleen, Mouse thymus, Rat thymus
- Immunogen sequence: TGQPLKEDPS AVPVFSVDYG ELDFQWREKT PEPPVPCVPE QTEYATIVFP SGMGT
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC.
PD-1 binds two related ligands, PDL-1 and PDL-2. Upon binding, PD-1 generates inhibitory signals that suppress immune activation in the absence of “danger signals” such as LPS or other pathogen-associated molecules.
PD-1 deficiency in mice leads to hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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