Thermo Fisher Scientific HIP1R Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_0039501) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HIP1R,uniProtId:O75146-1,ncbiNodeId:9606,antigenRange:300-600,antigenLength:1068,antigenImageFileName:PA5-116542_HIP1R_O75146-1_Rabbit.svg,antigenImageFileNamePDP:PA5-116542_HIP1R_O75146-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2901173

Product Specific Information

Positive Samples: U-87MG, 293T, HeLa, Mouse brain, Mouse spleen, Mouse liver, Rat brain

Immunogen sequence: KPVVVIPEEA PEDEEPENLI EISTGPPAGE PVVVADLFDQ TFGPPNGSVK DDRDLQIESL KREVEMLRSE LEKIKLEAQR YIAQLKSQVN ALEGELEEQR KQKQKALVDN EQLRHELAQL RAAQLEGERS QGLREEAERK ASATEARYNK LKEKHSELVH VHAELLRKNA DTAKQLTVTQ QSQEEVARVK EQLAFQVEQV KRESELKLEE KSDQLEKLKR ELEAKAGELA RAQEALSHTE QSKSELSSRL DTLSAEKDAL SGAVRQREAD LLAAQSLVRE TEAALSREQQ RSSQEQGELQ G

Target Information

Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.