Thermo Fisher Scientific CD18 Monoclonal Antibody (WT.3), FITC
CD18 단백질을 인식하는 마우스 단일클론 항체로 FITC 형광 표지되어 있습니다. Flow Cytometry에 적합하며, 백혈구 부착 관련 연구에 활용됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): Neat dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WT.3 |
| Immunogen | FTL-43 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538457 |
Additional Formats
- PE (Cat. No. MA5-16985)
- Custom conjugation available upon request
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes. It forms heterodimers with CD11 molecules (CD11a–d) to constitute leukocyte (β2) integrins such as:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins are essential for leukocyte adhesion and migration. Absence or deficiency of CD18 leads to leukocyte adhesion deficiency type I (LAD1) and related immune dysfunctions. CD18 is also a receptor for Mannheimia haemolytica leukotoxin, mediating cytolysis in susceptible cells. Two transcript variants encoding CD18 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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