Thermo Fisher Scientific F13B Monoclonal Antibody (OTI1A3), TrueMAB
인간 F13B 단백질(아미노산 357-661)에 특이적인 단일클론 항체로 Western blot에 적합. Mouse IgG1 형식의 TrueMAB 제품으로 액상 형태, 1 mg/mL 농도. 고순도 친화성 크로마토그래피 정제, 안정적인 PBS/BSA/glycerol 저장 버퍼 구성.
- 카탈로그번호
- TA805990
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB)
Tested Dilution
- 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 357–661 of human F13B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of 2 A subunits, identical to those of plasma origin.
Upon activation by thrombin cleavage and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme, factor XIIIa, identical to platelet factor XIII. This enzyme acts as a transglutaminase to catalyze gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot.
Factor XIII deficiency is classified into:
- Type I deficiency: lack of both A and B subunits
- Type II deficiency: lack of the A subunit alone
These defects can lead to lifelong bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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