Thermo Fisher Scientific F13B Monoclonal Antibody (OTI2H10), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:200

Product Specifications

Target Information

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII consists only of 2 A subunits, which are identical to those of plasma origin.

Upon activation by cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot.

Factor XIII deficiency is classified into two categories:

• Type I deficiency: lack of both A and B subunits
• Type II deficiency: lack of A subunit alone

These defects can result in lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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