Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI7C9)
Thermo Fisher Scientific의 UFD1L 단클론 항체(OTI7C9)는 인간 UFD1L 단백질을 특이적으로 인식하는 Mouse IgG2b 형 항체입니다. Western blot과 IHC(Paraffin) 실험에 적합하며, 고순도 Affinity Chromatography로 정제되어 안정적인 신뢰성을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7C9 |
| Immunogen | Full length human recombinant protein of UFD1L produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725625 |
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, which then potentiates proteolytic degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
The UFD1 protein was first characterized in yeast and later identified in humans as UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions with amino acid substitutions at Gly76 by promoting selective multiubiquitination.
Mutations in UFD1 are linked to CATCH22 syndrome, involving cardiac defects, cleft palate, and hypocalcemia, suggesting its role in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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