Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI8G6)
UFD1L 단백질을 인식하는 Thermo Fisher의 단클론 항체로, Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, 마우스 IgG1 아이소타입. 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8G6 |
| Immunogen | Full length human recombinant protein of UFD1L produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725626 |
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on target proteins, leading to their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway. The UFD1 protein, first identified in S. cerevisiae, and its human homolog UFD1L, regulate this process by modulating multiubiquitination of Ub-conjugates. Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a role in developmental proteolytic regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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