Thermo Fisher Scientific SSTR3 Monoclonal Antibody (OTI1A1), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Target Information

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs, leading to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions involved in the negative regulation of GPCRs.
This “turn-off” activity has important implications for cellular physiological actions and continues to drive pharmacological research for new drug candidates.
Two notable GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have significant market shares in mental health and allergy treatments, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.