Thermo Fisher Scientific MAPK7 Monoclonal Antibody (OTI4C1), TrueMAB
MAPK7(ERK5) 단백질을 인식하는 마우스 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관됩니다. 세포 신호전달 및 발달 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C1 |
| Immunogen | Full length human recombinant protein of human MAPK7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.59 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family involved in diverse cellular processes such as proliferation, differentiation, transcription regulation, and development. It is activated by MAP2K5/MEK5 and participates in downstream signaling of various receptors. Upon extracellular stimulation, MAPK7 translocates to the nucleus to regulate gene expression through phosphorylation of transcription factors. Gene deletion in mice leads to defective vascular and cardiac development, indicating its essential role in endothelial function and vessel integrity. Four alternatively spliced transcript variants encoding two distinct isoforms have been reported. ERK5 is expressed in many adult tissues, particularly in heart, placenta, lung, kidney, and skeletal muscle, but not in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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