Thermo Fisher Scientific DLG3 Monoclonal Antibody (OTI3F2), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of this family, SAP102 has three approximately 90 amino acid repeats called PDZ domains, followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain.
It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering, contributing to neuronal plasticity. SAP102 is believed to participate in clustering of proteins such as NMDA receptors and shaker-type potassium channels at synaptic membranes in CNS neurons.
NMDA receptors and Shaker-type potassium channels share a C-terminal sequence motif (T/SXV), which may mediate interaction with SAP102 PDZ domains. Other neuronal proteins (e.g., β1 adrenergic receptor, some serotonin receptors, sodium channel subunits) may also interact through this motif. Neuronal nitric oxide synthase (nNOS), lacking the T/SXV motif but containing a PDZ domain, has been shown to associate with SAP102 via pseudo-homotypic PDZ-PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.