Thermo Fisher Scientific MAPK7 Monoclonal Antibody (OTI2F1), TrueMAB
인간 MAPK7(ERK5)을 인식하는 Mouse IgG1 단일클론 항체로, WB, ICC/IF, Flow Cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보관되며 -20°C에서 안정적입니다. 세포 신호전달 연구용으로 최적화된 TrueMAB 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F1 |
| Immunogen | Full length human recombinant protein of human MAPK7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.74 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in various cellular processes such as proliferation, differentiation, transcription regulation, and development. It is activated by MAP2K5/MEK5 and participates in downstream signaling of multiple receptors. Upon extracellular stimulation, MAPK7 translocates to the nucleus to regulate gene expression through phosphorylation of transcription factors. Gene deletion in mice causes defective vascular and cardiac development, leading to embryonic lethality. MAPK7 is essential for endothelial function and vascular integrity. Four alternatively spliced transcript variants encoding two distinct isoforms have been reported. ERK5 is abundantly expressed in heart, placenta, lung, kidney, and skeletal muscle, but not in liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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