Thermo Fisher Scientific c-Myc Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays key roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with cell proliferation and cycle regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to amino- or carboxy-termini of target proteins.
Amplification of the c-Myc gene has been found in several human tumors including lung, breast, and colon carcinomas, while N-Myc amplification occurs in neuroblastomas. Translocation of the c-Myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is associated with Burkitt’s lymphoma and other B-cell lymphoproliferative conditions. Aberrant c-Myc expression occurs in diverse tumors such as colorectal, gastric, hepatic, mammary, ovarian, thyroidal, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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