Thermo Fisher Scientific c-Myc Polyclonal Antibody, HRP
Thermo Fisher Scientific의 c-Myc Polyclonal Antibody, HRP는 인간 c-Myc 단백질을 인식하는 고품질 Rabbit IgG 항체입니다. Western blot에 최적화되어 있으며 HRP 결합형으로 신속한 검출이 가능합니다. 종양 관련 연구 및 세포 증식, 분화, 세포주기 조절 연구에 적합합니다.
- 카탈로그번호
- PA5141144
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human C-myc aa 390–439 |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA, 40% glycerol |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2932595 |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is frequently activated in various tumor cells and plays a critical role in:
- Cellular proliferation, differentiation, apoptosis, and cell cycle progression
- Regulation via phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK
- Vasculogenesis and angiogenesis during tumor development
Antibodies against c-Myc epitopes recognize Myc-tagged proteins at either amino- or carboxy-termini. Amplification of c-Myc is observed in lung, breast, and colon carcinomas, while N-Myc amplification occurs in neuroblastomas. Translocation of the c-Myc locus is associated with Burkitt’s lymphoma and other B-cell proliferative disorders. Aberrant expression of c-Myc is found in diverse tumors, including colorectal, gastric, hepatic, ovarian, and hematopoietic neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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