Thermo Fisher Scientific KV4.1 (KCND1) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:400

Product Specifications

Product Specific Information

• Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
• Storage: Ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
• Reconstituted Solution: Store at 4°C for up to 1 week. For longer storage, aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
• Preparation: Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The KV gene family encodes over 30 genes forming the subunits of K⁺ channels, exhibiting diversity in gating, permeation properties, and expression patterns. Functional KV channels assemble as tetramers of pore-forming alpha-subunits (KVα), including KV1, KV2, KV3, and KV4 proteins, and accessory KVβ subunits that modify gating properties. Variations in trafficking, processing, and surface expression of major KV1 subunits (KV1.1, KV1.2, KV1.4) in rat and human brain indicate that subunit regulation is crucial for proper neuronal channel formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.