Thermo Fisher Scientific KV2.2 (KCNB2) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200

Product Specifications

Product Specific Information

• Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size
• Ships as a lyophilized powder at room temperature
• Upon arrival: store at -20°C
• Reconstituted solution: stable at 4°C for up to 1 week
• For long-term storage: aliquot and store at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

Kcnb2 (Kv2.2) encodes a voltage-gated K⁺ channel that is a key determinant of neuronal membrane excitability.
Differences in K⁺ channel expression and density contribute to variations in action potential waveforms and repetitive firing patterns among neuronal cell types.
Delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, Kv2.2) are expressed in neuronal somata, proximal dendrites, and various non-neuronal cells including pancreatic islets, alveolar cells, and cardiac myocytes.

Kv2.1 and Kcnb2 form distinct K⁺ channel populations, primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates voltage-dependent potassium ion permeability of excitable membranes, opening or closing in response to membrane potential differences.

Diseases associated with KCNB2 include Brugada Syndrome.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.