Thermo Fisher Scientific PD-1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
WFLDSPDRPW NPPTFSPALL VVTEGDNATF TCSFSNTSES FVLNWYRMSP SNQTDKLAAF PEDRSQPGQD CRFRVTQLPN GRDFHMSVVR ARRNDSGTYL CGAIS

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC).
T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC.
PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either ligand, signals generated by PD-1 inhibit activation of the immune response in the absence of “danger signals” such as LPS or other pathogen-associated molecules.
Evidence for this is seen in PD1- mice who exhibit hyperactivated immune systems and autoimmune diseases.
Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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