Thermo Fisher Scientific PTGR2 Polyclonal Antibody
PTGR2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)와 높은 특이성을 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 228–273 of human ZADH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553906 |
Product Specific Information
- Detects endogenous PTGR2 protein at ~38 kDa.
- Purity >95% by SDS-PAGE.
Target Information
ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2, or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein belonging to the NADP-dependent oxidoreductase L4BD family.
It functions as a 15-oxoprostaglandin 13-reductase, catalyzing the conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2 in a NADPH-dependent manner.
ZADH1 overexpression represses PPAR gamma transcriptional activity and adipocyte differentiation. It is widely expressed, with highest levels in heart, kidney, liver, pancreas, and prostate, and moderate levels in brain, small intestine, lung, testis, and skeletal muscle.
ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms encoded on human chromosome 14q24.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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