Thermo Fisher Scientific CD8A Monoclonal Antibody (OTI7C10), TrueMAB

Applications

Product Specifications

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family that plays a critical role in signal transduction, T cell differentiation, and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. Its counterpart, CD4, serves as a co-receptor for MHC class II molecules.

CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as disulfide-linked homodimers. Engagement of MHC-I/peptide complexes by antigen-presenting cells triggers recruitment of lymphocyte-specific protein tyrosine kinase (Lck), leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are essential for the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.