Thermo Fisher Scientific ZNF598 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZNF598. Recombinant protein control fragment (Product #RP-98748). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZNF598,uniProtId:Q86UK7-1,ncbiNodeId:9606,antigenRange:300-413,antigenLength:904,antigenImageFileName:PA5-59712_ZNF598_Q86UK7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-59712_ZNF598_Q86UK7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2650225

Product Specific Information

Immunogen sequence: VVGGEDYEEV DRYSRQGRVA RAGTRGAQQS RRGSWRYKRE EEDREVAAAV RASVAAQQQE EARRSEDQEE GGRPKKEEAA ARGPEDPRGP RRSPRTQGEG PGPKETSTNG PVSQ

Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 78%.

Target Information

ZNF598 (E3 ubiquitin-protein ligase ZNF598) plays a key role in the ribosome quality control (RQC). RQC is a pathway that takes place when a ribosome has stalled during translation. It is required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40A ribosomal protein RPS10/eS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiated the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.