Thermo Fisher Scientific Phospho-CREB (Ser271) Polyclonal Antibody
CREB 단백질의 Ser271 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 ICC/IF에 적합. Human, Mouse, Rat 시료 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. -20°C 보관, 동결·해동 반복 피할 것.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-CREB (Ser-271) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding Ser-271 in human CREB. This sequence is well conserved in rat, mouse, chicken, and zebrafish CREB. The site has some homology to the conserved site in ATF1 (Ser-198) and CREM (Ser-287). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2942899 |
Product Specific Information
This antibody detects a 43 kDa protein corresponding to the molecular mass of CREB on SDS-PAGE immunoblots of human A431, Jurkat, and rat PC12 cells treated with Calyculin A, but is not observed after lambda phosphatase treatment.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors.
Activation of CREB depends on phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1.
Although CREB binds DNA independent of phosphorylation, only the phosphorylated form acts as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator, binds to CREB near serine 133.
CREB is involved in processes such as circadian rhythm synchronization, adipocyte differentiation, and learning and memory. The human gene is located on chromosome 2q.
CREB dysfunction is associated with Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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