Thermo Fisher Scientific PTEN Monoclonal Antibody (2F4C9)
PTEN 단백질을 특이적으로 인식하는 mouse monoclonal antibody (Clone 2F4C9). Western blot, IHC, ICC/IF, ELISA 등 다양한 응용 가능. Human 및 Mouse 반응성 확인. Protein A로 정제된 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 0.5 µg/mL | View 1 publication |
| ELISA | 0.1–1 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F4C9 |
| Immunogen | Recombinant protein derived from the PTEN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533087 |
Product Specific Information
Antibody 32-5800 reacts specifically with human PTEN protein. Reactivity was confirmed with cell lines containing endogenous PTEN (NIH3T3, K652, DU145) and transfected cell lines (Rat1, 293T). Detects ~55 kDa PTEN protein and is effective in western blot analysis of breast cancer cell lines. No cross-reactivity to other proteins observed.
Target Information
PTEN is a tumor suppressor gene frequently mutated in various cancers. It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase with both tensin-like and catalytic domains similar to dual specificity tyrosine phosphatases. PTEN dephosphorylates phosphoinositide substrates, negatively regulating intracellular PI(3,4,5)P3 levels and the AKT/PKB signaling pathway. It plays a key role in AKT-mTOR signaling, influencing neuron integration, dendritic development, and synapse formation. PTEN also negatively regulates insulin signaling and glucose metabolism in adipose tissue. Nuclear monoubiquitinated PTEN exhibits higher apoptotic potential, while cytoplasmic nonubiquitinated PTEN shows reduced tumor suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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