Thermo Fisher Scientific PSMC3IP Polyclonal Antibody
Human PSMC3IP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Affinity chromatography로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 세포 내 HOP2 단백질 검출에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PSMC3IP (Accession Q9P2W1), corresponding to amino acid residues R166–D216 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850069 |
Product Specific Information
Antibody detects endogenous levels of total HOP2.
Target Information
PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis.
The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA.
This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single-strand DNA to capture double-strand DNA. It stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing.
It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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