Thermo Fisher Scientific HERC5 Polyclonal Antibody
HERC5 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 실험에 적합하며, 인간·마우스·랫 종에서 반응. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HERC5 (Accession Q9UII4), corresponding to amino acid residues G303–E353 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850064 |
Product Specific Information
Antibody detects endogenous levels of total HERC5.
Target Information
HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts as a positive regulator of the innate antiviral response in cells induced by interferon.
HERC5 functions as part of the ISGylation machinery that recognizes target proteins broadly and non-specifically. It catalyzes ISGylation of IRF3, resulting in sustained activation, attenuates IRF3–PIN1 interaction (which antagonizes IRF3 ubiquitination and degradation), and enhances the antiviral response.
HERC5 is physically associated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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