Thermo Fisher Scientific SARS-CoV-2 Neutralizing Monoclonal Antibody (5B7D7)
SARS-CoV-2 스파이크 단백질 RBD를 표적으로 하는 중화 모노클론 항체로, ELISA·Flow Cytometry·Neutralization 등 다양한 연구용 응용 가능. Mouse IgG1, kappa 형식으로 액상 형태 제공. -20°C 보관, Wet ice 배송.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
| Neutralization (Neu) | 1–10 µg/mL |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B7D7 |
| Immunogen | Recombinant SARS-CoV-2 Spike protein fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
Product Specific Information
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus that caused COVID-19. It contains glycosylated spike (S) protein composed of S1 and S2 subunits. The S1 subunit includes a receptor-binding domain (RBD) that binds to ACE2 receptor on target cells.
Target Information
SARS-CoV-2, also known as 2019-nCoV, causes illnesses ranging from mild cold-like symptoms to severe respiratory distress. The CoV Spike (S) protein is crucial for viral attachment, fusion, and entry, and serves as a target for antibody and vaccine development.
The Spike protein receptor-binding domain (RBD, S-RBD) binds strongly to human and bat ACE2 receptors, showing higher affinity than SARS-CoV RBD. The full-length SARS-CoV-2 Spike protein (1273 amino acids) includes:
- Signal peptide (aa 1–13)
- S1 subunit (aa 14–685): receptor binding
- S2 subunit (aa 686–1273): membrane fusion
The S-ECD represents the extracellular domain of the Spike protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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