Thermo Fisher Scientific CD21 Monoclonal Antibody (2G9)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-11417 targets CD21 in WB, FACS, and IHC (P) applications and shows reactivity with human samples.
This antibody is not suitable for Raji cell lysates or mouse BAF-3 cell lysates in Western blot analysis.
The MA5-11417 immunogen is recombinant protein encoding the external domain of human CD21.

Target Information

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigens.
CD21 plays important roles in uptake and retention of immunocomplexes, survival of memory B cells, and development and maintenance of the humoral response to T-dependent antigens.
It serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells, expediting neuroinvasion following peripheral exposure to prions.
A soluble form of CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
CD21 functions as a receptor for C3d, C3dg, and iC3b complement components, for EBV, and for IFNα.
It binds to CD23 and associates with CD19, CD81, and Leu13 to form a large signal-transduction complex involved in B cell activation.
Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different isoforms of CD21 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.