Thermo Fisher Scientific WDR48 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
SDMLQVRKVM EHVYEKIINL DNESQTTSSS NNEKPGEQEK EEDIAVLAEE KIELLCQDQV LDPNMDLRTV KHFIWKSGGD LTLHYR

Antigen sequence identity:

• Mouse: 99%
• Rat: 99%

Target Information

WD-repeats are motifs found in various proteins, characterized by a conserved core of 40–60 amino acids forming a propeller-like structure. Proteins containing WD-repeats participate in diverse cellular functions such as signal transduction, apoptosis, transcriptional regulation, and cell cycle control. These repeats mediate protein-protein interactions and facilitate complex assembly.

WDR48 (WD repeat-containing protein 48), also known as USP1-associated factor 1 or p80, is a 677-amino-acid protein that regulates deubiquitinating complexes via activation of USP1, USP12, and USP46. It enhances deubiquitination by increasing catalytic turnover without altering substrate affinity. WDR48 is ubiquitously expressed and mainly localized to the cytoplasm. Five isoforms are expressed due to alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.