Thermo Fisher Scientific CD63 (Late Endosomes Marker) Monoclonal Antibody (LAMP3/2789)
CD63 단백질을 타깃으로 하는 Thermo Fisher Scientific의 단클론 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot, IHC 등 다양한 어플리케이션에 사용 가능하며 Protein A/G로 정제된 액상 형태입니다. 4°C 보관, 동결 금지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LAMP3/2789 |
| Immunogen | Recombinant human CD63 protein fragment (around aa100–197) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD63 (also known as LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein belonging to the tetraspanin family. It is located in late endosomes, lysosomes, and secretory vesicles of various cell types. CD63 can also be found on the plasma membrane following cell activation and is widely used as a basophil activation marker.
In mast cells, CD63 expression does not require activation. It interacts with integrins, influencing phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and ROMK1 channel regulation. CD63 also functions as a T-cell costimulatory molecule and its expression can serve as a prognostic marker in early-stage carcinomas.
CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. It is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40. CD63 dysfunction is linked to diseases such as melanoma and Hermansky-Pudlak Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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