Thermo Fisher Scientific SMC6 Polyclonal Antibody
SMC6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. WB, IHC, ICC, Flow 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5–1 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| Flow Cytometry (Flow) | 1–3 µg/1×10⁶ cells | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human SMC6L1 recombinant protein (Position: D205–E443) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2747157 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Core component of the SMC5-SMC6 complex, which is involved in DNA double-strand break repair by homologous recombination. This complex promotes sister chromatid recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. It is essential for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex components, leading to disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. The SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genomes (PubMed:26983541). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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