Thermo Fisher Scientific CD146/MCAM Polyclonal Antibody
CD146/MCAM 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 Protein A 정제, 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CD146, amino acids 201–300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in all endothelial cells and in various normal and malignant cell types. CD146 functions as a calcium-independent cell adhesion molecule and may also participate in signal transduction by recruiting Fyn kinase, leading to tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly.
CD146 plays a role in cell adhesion and cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may facilitate melanoma cell interaction with vascular elements, promoting hematogenous tumor spread. Additionally, CD146 may act as an adhesion molecule in neural crest cells during embryonic development and serve as a surface receptor triggering tyrosine phosphorylation of FYN and PTK2, along with transient intracellular calcium increase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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