Thermo Fisher Scientific FOX3/NeuN Polyclonal Antibody
FOX3/NeuN 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. 인간, 생쥐, 토끼, 랫트 반응성. Protein A 정제, 액상 형태, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NeuN, amino acids 51–150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fox-3, also known as NeuN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. It is localized in both the nucleus and cytoplasm and is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which accounts for over 2.5% of the human genome and encodes more than 1,200 genes.
Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1.
- p53 maintains cellular genetic integrity through DNA repair and apoptosis regulation.
- BRCA1 is directly involved in DNA repair and is linked to early-onset breast cancer and predisposition to various cancers, including ovary, colon, prostate, and fallopian tube.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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