Thermo Fisher Scientific Phospho-c-Abl (Tyr185) Polyclonal Antibody
Phospho-c-Abl (Tyr185) 폴리클로날 항체로, 인산화된 Tyr185 부위의 c-Abl 단백질을 특이적으로 인식합니다. Western blot 및 Immunocytochemistry에 적합하며, Human, Mouse, Rat 등 다양한 종에 반응합니다. 고순도 정제 및 안정적 보관이 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-c-Abl (Tyr185) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABL1 (Accession P00519), corresponding to amino acid residues around phosphorylated Tyr185. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818276 |
Product Specific Information
This antibody detects endogenous levels of c-Abl only when phosphorylated at Tyr185, a site historically referenced as Tyr204.
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
c-Abl activity is negatively regulated by its SH3 domain, and deletion of this domain transforms it into an oncogene. The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, indicating a cell cycle role.
In chronic myelogenous leukemia (CML) and certain acute lymphoblastic leukemias (ALL), the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation, forming the Philadelphia chromosome, which fuses c-Abl sequences from chromosome 9 with the Bcr gene on chromosome 22.
The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). It may regulate DNA repair by activating pro-apoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.