Thermo Fisher Scientific DWORF Polyclonal Antibody
Thermo Fisher Scientific의 DWORF 폴리클로날 항체는 마우스 단백질을 대상으로 한 연구용 항체입니다. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합하며, 높은 특이성과 순도를 제공합니다. 액상 형태로 안정적인 저장 및 운송이 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–30 of mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DWORF enhances the activity of ATP2A1/SERCA1 ATPase in the sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (PubMed:26816378, PubMed:30299255).
It does not directly stimulate SERCA pump activity (PubMed:26816378).
DWORF enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN), and myoregulin (MRLN) (PubMed:26816378, PubMed:30299255).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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