Thermo Fisher Scientific Phospho-KAP-1 (Ser824) Recombinant Rabbit Monoclonal Antibody (BL-246-7B5)

Thermo Fisher Scientific Phospho-KAP-1 (Ser824) Recombinant Rabbit Monoclonal Antibody (BL-246-7B5)

Applications and Tested Dilution

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (IHC): Assay-dependent
• Immunocytochemistry (ICC/IF): Assay-dependent
• Flow Cytometry (Flow): Assay-dependent
• Immunoprecipitation (IP): Assay-dependent
• Gel Shift (GS): Assay-dependent

Product Specifications

Product Specific Information

Product is tested in SW-Size.

Target Information

The KRAB (Kruppel-associated box) domain, approximately 45 amino acids in length, is a transcriptional repression domain found in numerous transcription factors. Over 220 KRAB-zinc finger protein (KRAB-ZFP) genes have been identified in the human genome. These proteins repress transcription through interactions with KAP-1 (KRAB-associated protein 1), an 835 amino acid polypeptide containing a RING finger, B boxes, and a PHD finger.
KAP-1 forms complexes with KRAB-domain transcription factors to enhance repression efficiency and interacts directly with HP1 (heterochromatin protein 1) and KRAZ1 (KRAB-containing zinc finger protein 1). KAP-1 targets KRAZ1 to centromeric heterochromatin foci containing HP1α, regulating transcriptional repression. Mutations that disrupt HP1 binding lead to random KRAZ1 distribution and strong transcriptional activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)