Thermo Fisher Scientific CRMP1 Polyclonal Antibody
CRMP1 단백질을 검출하기 위한 Thermo Fisher Scientific의 다클론 항체로, 인간·마우스·랫트 반응성. WB, IHC, ICC/IF 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체. 신경세포 성장 및 분화 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–4 µg/mL | View 6 publications |
| Immunohistochemistry (IHC) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the center of human CRMP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154100 |
Product Specific Information
- Suggested positive control: Caco-2 cell lysate
- PA5-20176 can be used with blocking peptide PEP-0293
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain, where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in regions of high synaptic remodeling such as the cerebellum, hippocampus, and olfactory system suggests involvement in adult brain plasticity.
CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in the brain. Later studies have shown its role in neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization shifts from axonal to somatodendritic as neurons reach functional maturity, indicating its involvement in both early neuronal differentiation and later processes related to neuronal survival or death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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