Thermo Fisher Scientific TLR1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Suggested positive control: Daudi cell lysate
• PA5-20182 can be used with blocking peptide PEP-0297

Target Information

TLR1 protein is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) expressed on infectious agents and mediate cytokine production necessary for effective immunity.
The mammalian TLR family comprises transmembrane proteins characterized by multiple leucine-rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. TLRs may constitute an important component of innate immunity in humans. In mice, TLR1 interacts with TLR2, and co-expression enhances NF-kappaB activation in response to synthetic lipopeptides. They recognize lipid configurations of native mycobacterial lipoproteins and several tri-acylated lipopeptides. Different transcript lengths have been noted for the TLR1 gene, resulting from alternative polyadenylation or splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.