Thermo Fisher Scientific AES Polyclonal Antibody
AES 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ICC/IF에 적합하며, 인간과 생쥐 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로 안정적인 신호 검출 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 2–4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the amino-terminus of human AES |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153097 |
Product Specific Information
- Suggested positive control: 293 cell lysate
- PA5-20170 can be used with blocking peptide PEP-0287.
Target Information
Adhesion to the extracellular matrix regulates cell survival through integrin engagement and cell spreading. Anoikis is apoptosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is part of the Groucho/transducin-like enhancer of split (TLE) family of transcriptional co-repressors, involved in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein released during apoptosis. This complex may suppress survival-promoting gene transcription regulated by TLE proteins. Apoptosis of AES and Bit1-transfected cells can be inhibited via attachment to fibronectin through α5β1 integrin, indicating that the Bit1-AES pathway contributing to anoikis is integrin-regulated, particularly by α5β1 integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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