Thermo Fisher Scientific ROR gamma (t) Polyclonal Antibody
ROR gamma(t) 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C 또는 -20°C에서 보관 가능합니다.
- 카탈로그번호
- PA586733
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 114–159 of Human RORgamma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803493 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
ROR gamma, a NR1 Thyroid Hormone-Like receptor, influences thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis.
It promotes thymocyte survival by activating Bcl-x(L) expression and is essential for lymph node and Peyer’s patch development.
The thymus-specific isoform ROR gamma(t) inhibits Fas ligand expression and cytokine secretion in immature thymocytes.
ROR gamma binds as a monomer to response elements with a single GGTCA motif preceded by a 6 bp AT-rich sequence.
Expression is observed in mouse thymus, adipose, bone, skeletal muscle, liver, kidney, and in human skeletal muscle.
ESTs have been identified in various human tissue libraries, including cancerous and normal tissues.
ROR gamma(t) (RORgt) is an isoform of RORC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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