Thermo Fisher Scientific alpha Synuclein Polyclonal Antibody
Thermo Fisher Scientific의 알파 시뉴클레인 폴리클로날 항체로, 인간, 마우스, 랫트에 반응합니다. WB, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제된 고품질 항체입니다. 파킨슨병 연구 등 신경퇴행성 질환 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Bacteria, C. elegans, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full-length human alpha Synuclein recombinant protein (UniProt ID: P37840-1, amino acids 1–140) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.15 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792485 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (83%), Pig (97%), Chicken (86%), Sheep (95%), Chimpanzee (100%), Bovine (94%).
- Positive Control: U87-MG, SK-N-SH, IMR-32, SK-N-AS, mouse brain, rat brain.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, encoding alpha-synuclein, are implicated in Parkinson’s disease pathogenesis. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease brains. Multiple alternatively spliced transcripts encoding different isoforms have been identified. Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia with Lewy Bodies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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