Thermo Fisher Scientific KChIP3 Polyclonal Antibody
KChIP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. Human 및 Mouse 반응성. 고순도 Protein G 정제, 액상 형태로 제공되며 4°C 또는 -20°C에서 안정 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1–30 amino acids from the N-terminal region of human KChIP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.6 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2132611 |
Target Information
Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain, these channels prevent reverse-propagation of action potentials.
Associated with Kv4 channels are calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate their function. There are three known KChIPs:
- KChIP1: Expressed in the brain
- KChIP2: Expressed in brain, heart, and lung (three isoforms: a, b, c)
- KChIP3: Also known as calsenilin and DREAM (DRE-antagonist modulator), expressed in brain and testis
KChIP3 functions as a DNA-binding transcriptional regulator, repressing transcription from the early-response gene c-fos. It is also associated with presenilins and implicated in beta-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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