Thermo Fisher Scientific ATP2C1 Polyclonal Antibody
Human ATP2C1 단백질을 인식하는 Rabbit polyclonal antibody로, IHC(P)에서 1:1,000~1:2,500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. Hailey-Hailey disease 관련 연구 및 IGF1R 처리 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ATP2C1 (Product #RP-95777) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2856463 |
Product Specific Information
Immunogen sequence:
AIASRLGLYS KTSQSVSGEE IDAMDVQQLS QIVPKVAVFY RASPRHKMKI IKSLQKNGSV VAMTGD
Target Information
ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA1), is a magnesium-dependent enzyme that catalyzes ATP hydrolysis coupled with calcium transport from the cytosol to the Golgi lumen.
Defects in ATP2C1 cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin.
ATP2C1 is ubiquitously expressed, showing a lower maximal turnover rate for Ca2+-ATPase reaction and a higher affinity for cytosolic Ca2+ activation compared to ATP2C2.
Recent studies indicate ATP2C1 regulates insulin-like growth factor receptor (IGF1R) processing in tumor progression of basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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