Thermo Fisher Scientific ARID1A Recombinant Rabbit Monoclonal Antibody (HL2304)

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin.

It possesses at least two conserved domains that could be important for its function:

1. A DNA-binding domain that specifically binds an AT-rich DNA sequence recognized by a SNF/SWI complex at the beta-globin locus.
2. A C-terminal domain that stimulates glucocorticoid receptor-dependent transcriptional activation.

The protein encoded by this gene is believed to confer specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.