Thermo Fisher Scientific CD31 (PECAM-1) Recombinant Rabbit Monoclonal Antibody (2H9S5)
CD31(PECAM-1) 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 모노클로날 항체입니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며 인간 및 생쥐 시료에 반응합니다. 고순도 친화 크로마토그래피 정제, 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2H9S5 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 630–738 of CD31/PECAM1 (NP_0004334) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.55 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2898043 |
Product Specific Information
- Positive Samples: THP-1, Mouse lung
- Immunogen sequence:
AKQMPVEMSR PAVPLLNSNN EKMSDPNMEA NSHYGHNDDV RNHAMKPIND NKEPLNSDVQ YTEVQVSSAE SHKDLGKKDT ETVYSEVRKA VPDAVESRYS RTEGSLDGT
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is widely expressed within the vascular system, primarily at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, important for cell-cell interactions.
This multifunctional molecule plays key roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis. It is a critical regulatory component of the vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: MA5-38125_CD31_PECAM-1_P16284-1_Rabbit_PDP.jpeg)
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