Thermo Fisher Scientific PAR4 Recombinant Rabbit Monoclonal Antibody (ARC1980)
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PAR4 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, ELISA에 적합합니다. 인간과 생쥐 시료에서 반응하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1980 |
| Immunogen | Synthetic peptide corresponding to amino acids 241–340 of human PAR4 (UniProt ID: Q96IZ0) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898048 |
Product Specific Information
- Positive Samples: HeLa, SW620, 293T, Mouse lung
- Immunogen sequence:
YSRTDRSGFP RYNRDANVSG TLVSSSTLEK KIEDLEKEVV RERQENLRLV RLMQDKEEMI GKLKEEIDLL NRDLDDIEDE NEQLKQENKT LLKVVGQLTR
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms.
- Intracellular mechanism: Inhibits pro-survival pathways and activates Fas-mediated apoptosis.
- Extracellular mechanism: Binds secreted protein to GRP78 on the cell surface, activating the extrinsic apoptotic pathway.
The gene is located on the unstable human chromosomal region 12q21 and is often deleted or mutated in various tumors. It also plays a role in age-related disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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