Thermo Fisher Scientific mGluR7 Polyclonal Antibody
Rabbit polyclonal antibody targeting mGluR7 (GRM7) for detection in WB, IHC-P, and ICC/IF. Recognizes human and bovine species. Antigen affinity purified, supplied as liquid at 1 mg/mL in PBS with 0.1% sodium azide. Suitable for neuroscience research o...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 6–16 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GRM7 / MGLUR7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551199 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Elephant, Bovine (100%).
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and may be altered in neuropathologic conditions.
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors divided into three groups based on sequence homology, signal transduction mechanisms, and pharmacologic properties:
- Group I: GRM1, GRM5 (activate phospholipase C)
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8
Groups II and III are linked to inhibition of the cyclic AMP cascade but differ in agonist selectivity. Multiple transcript variants encoding different isoforms have been identified for GRM7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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