Thermo Fisher Scientific mGluR7 Polyclonal Antibody
mGluR7 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 4–6 µg/mL 농도로 사용 가능. 다양한 종에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS에 0.1% sodium azide 포함, 4°C 또는 -20°C에서 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Horse, Human, Mouse, Non-human primate, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminal extracellular domain of human GRM7 / MGLUR7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551198 |
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups based on sequence homology, signal transduction mechanisms, and pharmacologic properties.
- Group I: GRM1, GRM5 — activate phospholipase C
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8
Groups II and III are linked to inhibition of the cyclic AMP cascade but differ in agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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