Thermo Fisher Scientific C4BPB Polyclonal Antibody
Thermo Fisher Scientific의 C4BPB 폴리클로날 항체는 인간, 마우스, 랫트에 반응하며 Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, PBS와 글리세롤 완충액에 보존되며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human C4BPB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720641 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation mediated through antibody targeting of foreign antigens. Structurally, C4BP is a disulfide-linked, multimeric protein composed of seven alpha chains and one beta chain. It functions as a cofactor for C3β inactivator in the cleavage of C3β and accelerates the decay of C4βC2α (C3 convertase) by acting as a cofactor in the cleavage of C4β by factor I. Certain Streptococcal strains expressing Ig-binding surface molecules can bind to overlapping C4β binding sites in C4BP, interfering with complement activation and reducing bacterial opsonization and phagocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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