Thermo Fisher Scientific c-Abl Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: K562, NT2D1
• Predicted reactivity: Mouse (83%), Rat (84%), Bovine (87%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of this domain turns c-Abl into an oncogene.
The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
In chronic myelogenous leukemia and some acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation, forming the Philadelphia chromosome, which fuses c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22.
The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating the proapoptotic pathway when DNA damage is irreparable.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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