Thermo Fisher Scientific IKK epsilon Polyclonal Antibody
IKK epsilon 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피로 정제. 인간 반응성, 1 mg/mL 농도, 액상 형태로 제공.
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Thermo Fisher Scientific IKK epsilon Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 494–710 of Human IKBKE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546770 |
Product Specific Information
- Recommended positive control: 293T cells
- Predicted reactivity: Bovine (86%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IKBKE acts as an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and suppression induces cell death. NF-κB is a key transcription factor mediating immune and inflammatory responses. It is inhibited by IκB proteins in the cytoplasm until phosphorylation by the IKK complex (IKK-α, IKK-β, and IKK-γ). A novel molecule, IKK-ι/IKK-i, has been identified in this complex. IKK epsilon is essential for NF-κB activation by PMA and T cell receptors but not by TNF-α or IL-1. Expression of IKK-ι/IKK-i is inducible by TNF-α, IL-1, and LPS.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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