Thermo Fisher Scientific AGO2 Monoclonal Antibody (R.386.2)
AGO2 단백질을 인식하는 Rabbit monoclonal antibody로, Western blot 및 Immunoprecipitation에 적합합니다. Human, Mouse, Rat 등 다양한 종에서 반응하며, RNA silencing 연구에 활용됩니다. 고순도 정제 및 안정적 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunoprecipitation (IP) | 1:50 | View 3 publications |
| RNA Immunoprecipitation (RIP) | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | R.386.2 |
| Immunogen | Synthetic peptide corresponding to mouse Argonaute 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 260 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10980123 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Ago proteins are broadly expressed in somatic cells, associate with miRNAs and are key actors in different RNA silencing pathways. Only the Ago2 protein displays endonucleolytic or “Slicer” activity and can execute miRNA-directed cleavage of target mRNA when base-pairing is perfect. In cases of partial complementarity, Ago2 represses translation instead of cleavage. Ago2 plays a non-redundant role in RNA interference, translation repression, and heterochromatinization. As a core element of the RISC complex, AGO2 initiates degradation of target mRNAs guided by siRNAs or miRNAs. It also acts as an RNA slicer in a Dicer-independent manner and regulates miRNA maturation. Over-expression of Ago2 is associated with tumor growth and cancer prognosis. Gene disruption studies in mice show that Ago2 is essential for embryonic development and regulates B-lymphoid and erythroid differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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