Thermo Fisher Scientific Phospho-JIP1 (Thr205) Polyclonal Antibody
JIP1 단백질의 Thr205 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 형태로 PBS와 50% glycerol에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JIP1 around the phosphorylation site of Thr205 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899231 |
Product Specific Information
Antibody detects endogenous levels of JIP1 only when phosphorylated at Thr205.
Target Information
The protein encoded by this gene is a regulator of pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to regulate c-Jun N-terminal kinase (MAPK8). This protein prevents MAPK8-mediated activation of transcription factors and decreases IL-1 beta and MEKK1-induced apoptosis in pancreatic beta cells. It also functions as a DNA-binding transactivator of the glucose transporter GLUT2. REST is reported to repress this gene in insulin-secreting beta cells. Mutations in this gene have been associated with type 2 diabetes susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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